p450 - publications

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1. Hum Biol. 2012 Feb;84(1):67-77.

Warfarin Pharmacogenetics: Polymorphisms of the CYP2C9, CYP4F2, and VKORC1 Loci
in a Genetically Admixed Omani Population.

Pathare AV, Zadjali SA, Misquith R, Alkindi SS, Panjwani V, Lapoumeroulie C,
Pravin S, Paldi A, Krishnamoorthy R.

1 Department of Hematology, Sultan Qaboos University Hospital.

Abstract This is the first study to evaluate the spectrum and prevalence of
dose-predictive genetic polymorphisms of the CYP2C9, CYP4F2 and VKORC1 loci
together, in a geographically defined, ethnically admixed healthy adult Omani
population sharing common lifestyle/environmental factors. Since the present-day
Omani population is the result of an admixture of Caucasian, African and Asian
ancestries, we compared the pharmacogenetic profile of these three loci in this
population. Interestingly, the Omani pharmacogenetic profile, in terms of allele
and genotype distribution, has values that are intermediate between Caucasians
and African Americans, the African admixture further substantiated by the
presence of the CYP2C9*8 allele. However, limitations and usefulness of such
comparisons warrant caution, as the data from pharmacogenetic literature do not
always represent bona fide population categories. Furthermore, definition of
study population based on microgeographical scale would be more appropriate in
pharmacogenetic research rather than the flawed racial, ethnic, or social
categorizations since pharmacogenetic variation is clinal, and genetic influences
will be further altered by lifestyle and environmental factors.

PMID: 22452429 [PubMed - in process]