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VKORC1 and CYP2C9 genotype is associated with over-anticoagulation during initiation of warfarin therapy in children.

J Thromb Haemost. 2012 Dec 27;

Authors: Biss TT, Avery PJ, Williams MD, Brandao LR, Grainger JD, Kamali F


Prediction of warfarin dose requirement in children is difficult and over-anticoagulation during initiation of warfarin is not uncommon. The role of genetic polymorphism in determining response to warfarin during initiation therapy is well established in adult patients; individuals who possess CYP2C9 and VKORC1 polymorphisms have a greater sensitivity to warfarin and are more likely to have a supra-therapeutic INR and serious bleeding during warfarin initiation than those who do not [1, 2]. Recent reports have indicated that VKORC1 and CYP2C9 genotype influence warfarin maintenance dose in children [3, 4] but their influence on outcomes during warfarin initiation has not been investigated. © 2012 International Society on Thrombosis and Haemostasis.

PMID: 23279643 [PubMed - as supplied by publisher]