p450 - publications
The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients.
Psychiatry Res. 2013 Apr 18;
Authors: Kohlrausch FB, Severino-Gama C, Lobato MI, Belmonte-de-Abreu P, Carracedo A, Hutz MH
We evaluated two polymorphisms at CYP1A2 (((⁎))1C and ((⁎))1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the ((⁎))1F/((⁎))1F genotype to be significantly associated with seizures and no relationship was observed with combinations of ((⁎))1F and ((⁎))1C alleles.
PMID: 23601795 [PubMed - as supplied by publisher]