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The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients.

Psychiatry Res. 2013 Apr 18;

Authors: Kohlrausch FB, Severino-Gama C, Lobato MI, Belmonte-de-Abreu P, Carracedo A, Hutz MH


We evaluated two polymorphisms at CYP1A2 (((⁎))1C and ((⁎))1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the ((⁎))1F/((⁎))1F genotype to be significantly associated with seizures and no relationship was observed with combinations of ((⁎))1F and ((⁎))1C alleles.

PMID: 23601795 [PubMed - as supplied by publisher]