p450 - publications

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1. J Med Case Reports. 2012 Feb 6;6(1):49. [Epub ahead of print]

Successful treatment of schizophrenia with melperone augmentation in a patient
with phenotypic CYP2D6 ultrarapid metabolization: a case report.

Gahr M, Gastl R, Kolle MM, Schonfeldt-Lecuona C, Freudenmann RW.

ABSTRACT: INTRODUCTION: There are limited treatment options for people with
schizophrenia with cytochrome P450 2D6 ultrarapid metabolizer status who do not
respond to amisulpride. Furthermore, the literature does not provide
evidence-based guidelines for this particular constellation. CASE PRESENTATION:
We report the case of a 50-year-old Caucasian female patient with schizophrenia
and cytochrome P450 2D6 ultrarapid metabolizer status who experienced an
insufficient antipsychotic effect with amisulpride. She was successfully treated
with melperone-augmented haloperidol. CONCLUSION: This report yields
melperone-augmented haloperidol as a possible pharmacological strategy in the
described situation. In addition, our observations support the available evidence
for the potential of melperone to act as an inhibitor of cytochrome P450 2D6.

PMID: 22309430 [PubMed - as supplied by publisher]