p450 - publications

Predict more p450 - ligand interactions now!


1. J Thromb Haemost. 2012 May 22. doi: 10.1111/j.1538-7836.2012.04788.x. [Epub ahead
of print]

Pharmacodynamic effect of clopidogrel therapy and switching to cilostazol in
patients with the CYP2C19 loss-of-function allele (ACCEL-SWITCH) study.

Jeong YH, Park Y, Muse WC, Kwon TJ, Koh JS, Hwang SJ, Kwak CH, Hwang JY.

Division of Cardiology, Department of Internal Medicine, Gyeongsang National
University Hospital, Jinju, Korea Sinai Center for Thrombosis Research,
Baltimore, Maryland, USA.

Restenosis and stent thrombosis (ST) are the catastrophic events in stented
patients. Despite development of drug-eluting stent (DESs) platform, selected
DES-treated patients still suffered from these clinical events [1]. Early events
(within post-stent 30 days) are more likely due to mechanical issues, inadequate
platelet inhibition, or prothrombotic profile, whereas late events may be
attributed to biological issues such as delayed re-endothelialization,
inflammation, impaired vascular function and vascular remodeling [2]. © 2012
International Society on Thrombosis and Haemostasis.

© 2012 International Society on Thrombosis and Haemostasis.

PMID: 22612904 [PubMed - as supplied by publisher]