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Interplay between Vitamin D and the Drug Metabolizing Enzyme CYP3A4.


J Steroid Biochem Mol Biol. 2012 Sep 14;


Authors: Wang Z, Schuetz EG, Xu Y, Thummel KE


Abstract

Cytochrome P450 3A4 (CYP3A4) is a multifunctional enzyme involved in both xenobiotic and endobiotic metabolism. This review focuses on two aspects: regulation of CYP3A4 expression by vitamin D and metabolism of vitamin D by CYP3A4. Enterohepatic circulation of vitamin D metabolites and their conjugates will be also discussed. The interplay between vitamin D and CYP3A4 provides new insights into our understanding of how enzyme induction can contribute to vitamin D deficiency.

PMID: 22985909 [PubMed - as supplied by publisher]