p450 - publications

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1. Bull Exp Biol Med. 2011 Aug;151(4):445-8.

Effects of CYP1A2 Gene Polymorphisms on Antipyrine CYP1A2-Dependent Metabolism.

[Article in English, Russian]

Chernyak YI, Itskovich VB, Kolesnikov SI.

Angarsk Affiliated Department of East Siberian Center of Human Ecology, the
Siberian Division of the Russian Academy of Medical Sciences, Russia.

The distribution of two CYP1A2 gene polymorphisms, CYP1A2*F and CYP1A2*D, was
studied in a group of 38 men. Antipyrine elimination test was carried out and
urinary cotinine was measured. The contribution of these CYP1A2 gene
polymorphisms, age, and tobacco smoking to accumulation of three main antipyrine
metabolites in the urine was evaluated by regression analysis. The impact of both
studied polymorphisms was essential for urinary levels of
3-hydroxymethylantipyrine (metabolite most dependent on cytochrome P-4501A2) and
hence, for functional activity of this isoform of the enzyme.

PMID: 22448362 [PubMed - in process]