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CYP2C9 and VKORC1 Gene Polymorphism is Inessential for Bleeding Development under Conditions of Oral Application of Anticoagulant Acenocoumarol in Russian Patients at High Risk of Thromboembolic Complications.

Bull Exp Biol Med. 2012 Oct;153(6):886-8

Authors: Sychev DV, Ignatyev IV, Emelyanov NV, Milovanova VV, Kossovskaya AV, Kukes IV, Tashenova AI, Kukes VG


The study included 52 patients at a high risk of thromboembolic complications, with permanent atrial fibrillation. All patients were treated with acenocoumarol for 6 months and the incidence of hemorrhages was evaluated in all of them. All patients were genotyped by CYP2C9 and VKORC1. The presence of CYP2C9*2 and CYP2C9*3 alleles of CYP2C9 locus and AA genotype of VCORC1 gene polymorphic G-1639(3673)A marker was not associated with the development of hemorrhages under conditions of acenocoumarol treatment (p=0.144 for CYP2C9, p=0.809 and 0.918 for VCORC1 in the total group and subgroup of patients with CYP2C9*1/*1 genotype, respectively). The search for other genetic markers of acenocoumarol efficiency and safety is needed for predicting the risk of hemorrhages during this treatment.

PMID: 23113310 [PubMed - in process]