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1. Pharmacogenomics. 2012 Apr;13(5):533-42.

CYP2C19 and PON1 polymorphisms regulating clopidogrel bioactivation in Chinese,
Malay and Indian subjects.

Chan MY, Tan K, Tan HC, Huan PT, Li B, Phua QH, Lee HK, Lee CH, Low A, Becker RC,
Ong WC, Richards MA, Salim A, Tai ES, Koay E.

National University Heart Centre, 1E Kent Ridge Road, Singapore 119228,

Aim, materials & methods: We investigated the functional significance of
CYP2C19*2, *3, *17 and PON1 Q192R SNPs in 89 consecutive Asian patients on
clopidogrel treatment and the prevalence of functionally significant
polymorphisms among 300 Chinese, Malays and Asian Indians. Results: Both CYP2C19
loss-of-function alleles (*2 or *3) were associated with higher platelet
reactivity while the CYP2C19 gain-of-function allele (*17) had lower platelet
reactivity. For PON1, the median PRI was not significantly different between the
QQ, QR and RR groups. The allele frequencies of CYP2C19*2, CYP2C19*3 and
CYP2C19*17 were 0.280, 0.065 and 0.010 (rare) for Chinese, 0.310, 0.050 and 0.025
for Malays, and 0.375, 0.010 (rare) and 0.165 for Indians, respectively.
Conclusion: Our data suggest that genotyping studies to investigate clopidogrel
response should include CYP2C19*2 and *3 but not *17 polymorphisms in Chinese,
and CYP2C19*2 and *17 polymorphisms but not *3 in Indians. All three
polymorphisms should preferably be genotyped in Malays. Original submitted 16
December 2011; Revision submitted 16 February 2012.

PMID: 22462746 [PubMed - in process]