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Challenges and limitations in interpretation of systematic reviews: Making sense of clopidogrel and CYP2C19 pharmacogenetics.

Clin Pharmacol Ther. 2013 May 13;

Authors: Sorich MJ, Polasek TM, Wiese MD


From 2010 to 2012 nine systematic reviews reported highly variable conclusions regarding the association between carriage of a cytochrome P450 2C19 loss-of-function allele and the risk of adverse cardiovascular events in individuals using clopidogrel. Possible contributors to the variable findings include differences in patient population, cardiovascular endpoints, and statistical models utilized by the systematic reviews, and unexplained heterogeneity, inconsistent/incomplete reporting, and risk of publication bias with respect to the primary studies.Clinical Pharmacology & Therapeutics (2013); accepted article preview online 13 May 2013; doi:10.1038/clpt.2013.100.

PMID: 23670120 [PubMed - as supplied by publisher]