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1. J Toxicol Environ Health A. 2012 Feb 15;75(4):232-41.

Allele and Genotype Frequencies of CYP2B6 and CYP2C19 Polymorphisms in Egyptian
Agricultural Workers.

Ellison CA, Abou El-Ella SS, Tawfik M, Lein PJ, Olson JR.

a Department of Pharmacology and Toxicology, School of Medicine and Biomedical
Sciences , University at Buffalo , Buffalo , New York , USA.

Genetic variability in cytochrome P-450 (CYP) has the potential to modify
pharmacological and toxicological responses to many chemicals. Both CYP2B6 and
CYP2C19 are pharmacologically and toxicologically relevant due to their ability
to metabolize multiple drugs and environmental contaminants, including the
organophosphorus (OP) pesticide chlorpyrifos. The aim of this study was to
determine the prevalence of CYP2B6 and CYP2C19 variants in an indigenous Egyptian
population (n = 120) that was shown to be occupationally exposed to chlorpyrifos.
Further, the genotyping data was compared for Egyptians with previously studied
populations to determine between population differences. Allelic frequencies were
CYP2B6 1459C > T (3.8%), CYP2B6 785A > G (30.4%), CYP2B6 516G > T (28.8%),
CYP2C19 681G > A (3.8%), and CYP2C19 431G > A (0%). The most prevalent CYP2B6
genotype combinations were CYP2B6 *1/*1 (44%), *1/*6 (38%), *6/*6 (8%), and *1/*5
(6%). The frequency of the CYP2C19 genotype combinations were CYP2C19 *1/*1
(93%), *1/*2 (6%), and *2/*2 (1%). The frequency of the CYP2B6 516G > T and
CYP2B6 785A > G polymorphisms in this Egyptian cohort is similar to that found
North American and European populations but significantly different from that
reported for West African populations, while that of CYP2B6 1459C > T is similar
to that found in Africans and African Americans. The observed frequency of
CYP2C19 681G > A in Egyptians is similar to that of African pygmies but
significantly different from other world populations, while CYP2C19 431 G > A was
significantly different from that of African pygmies but similar to other world
populations.

PMID: 22352331 [PubMed - in process]